PUBLICATIONS

Entire Pub Med index can be found here

Boston College

Engelberg K, Chen CT, Bechtel T, Sánchez Guzmán V, Drozda AA, Chavan S, Weerapana E, Gubbels MJ. The apical annuli of Toxoplasma gondii are composed of coiled-coil and signalling proteins embedded in the inner membrane complex sutures. Cell Microbiol. 2019 Aug 30;:e13112. doi: 10.1111/cmi.13112. PMID: 31470470

 

Gubbels, M.-J., and N. Morrissette. 2019. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (chapter 16). In: Toxoplasma gondii: The Model Apicomplexan, 3rd edition. Eds.: L.M. Weiss and K. Kim. Elsevier Academic Press. Submitted

Chen, C.-T. and M.-J. Gubbels. 2019. TgCep250 is dynamically processed through the division cycle and essential for structural integrity of the Toxoplasma centrosome. MBoC 30:1160-1169. PMID: 30865554

Coleman, B.I., S. Saha, S. Sato, K. Engelberg, D.J.P. Ferguson, I Coppens, M. Lodoen, and M.-J. Gubbels. 2018. A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion. mBio. 9: e01510-18. PMCID: PMC6168857

Berry, L., C.-T. Chen, M.E. Francia, A. Guerin, A. Graindorge, J.-M. Saliou, M. Grandmougin, S. Wein, C. Bechara, J. Morlon-Guyot, Y. Bordat, M.-J. Gubbels, M. Lebrun, J.-F. Dubremetz and W. Daher. 2018 Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle, a prerequisite for productive endodyogeny. Cell Molec Life Sci. 75:4417-4443 PMCID: PMC6260807

Dubey, R., B. Harrison, S. Dangoudoubiyam, G. Bandini, K. Cheng, A. Kosber, C. Agop Nersesian, D. Howe, J. Samuelson, D.J.P. Ferguson, M.-J. Gubbels. 2017. Differential roles for IMC proteins across Toxoplasma gondii and Sarcocystis neurona development. mSphere 2(5). pii: e00409-17. doi: 10.1128/mSphere.00409-17.

Saha, S., B.I. Coleman, R. Dubey, I.J. Blader, and M.-J. Gubbels. 2017. Two phosphoglucomutase paralogs facilitate ionophore-triggered secretion of the Toxoplasma micronemes. mSphere. 2: e00521-17.

 

Dubey, R., B.L. Staker, I.T. Foe, M. Bogyo, P.J. Myler, H.M. Ngô, and M.-J. Gubbels. 2017. Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. Mol. Microbiol. 103:618-634

Weidner, J.M., S. Kanatani, H. Uchtenhangen, M. Varas-Godoy, T. Schulte, K. Engelberg, M.-J. Gubbels, H. Song Sun, R. Harrison, A. Achour, and A. Barragan. 2016. Toxoplasma gondii 14-3-3 protein is linked to a hypermigratory phenotype in parasitized immune cells. Cell. Microbiol. 18:1537-1550. 

Carvalho, T.G., L. Berry, L. Reininger, C.-T. Chen, H. El Hajj, M. Bird, O. Kleifeld, S. Hermann, J. Morlon-Guyot, Y. Bordat, M. Lebrun, M.-J. Gubbels, C. Doerig, and W. Daher. 2016. The conserved apicomplexan Aurora kinase 3 is involved in endodyogeny, duplication rate and parasite virulence. Cell. Microbiol. 18:1106-1120 

Engelberg, K., F.D. Ivey, A. Lin, M. Kono, A. Lorestani, D. Faugno-Fusci, T.W. Gilberger, M. White, and M.-J. Gubbels. 2016.  A MORN1-assocatiated HAD phosphatase in the basal complex is essential for Toxoplasma gondii daughter budding. Cell. Microbiol. 18:1153-1171
 

Skariah, S., O. Walwyn, K. Engelberg, M.-J. Gubbels, N. Kim, B. Lynch, C. Gaylets, A. Ali Sultan, and D. Mordue. 2016.  Toxoplasma gondii’s FIKK kinase is not essential for the parasite’s lytic cycle . Int. J. Parasitol.  46:323-332  

 

Chen, C.-T., M. Farrell, J. de Leon, B. Nwagbara, P. Ebbert, D.J.P. Ferguson, L.A. Lowery, N. Morrissette, and M.-J. Gubbels. 2015. Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation. MBoC. 26:4562-4576  

Blader, I.J., B.I. Coleman, C.-T. Chen, and M.-J. Gubbels. 2015. The Toxoplasma gondii lytic cycle. Ann Rev Microbiol. 69:483-485  

 

Paul, A.S., S., Saha, K. Engelberg, R.Y. Jiang, B.I. Coleman, A.L. Kosber, C.-T. Chen, M. Ganter, N. Espy, T.-W. Gilberger, M.-J. Gubbels#, and M.T. Duraisingh#. 2015. Apicomplexan calcineurin regulates specific attachment of free parasites to host cells for infection. Cell Host Microbe. 18, 1-12  

Chen, C.-T., and M.-J. Gubbels. 2015. Apicomplexan cell cycle flexibility: centrosome controls the clutch. Trends Parasitol. 31:229-230  

Brown, K.M., E. Suvorova, A. Farrell, A. McLain, A. Dittmar, G.B. Wiley, G.T. Marth, P.M. Gaffney, M.-J. Gubbels, M. White, and I.J. Blader. . 2014. Forward genetic screening identifies a small molecule that blocks Toxoplasma growth by inhibiting both host- and parasite-encoded kinases PLoS Path. 10(6): e1004180  


Farrell, A., B.I. Coleman, B. Benenati, K.M. Brown, I. Blader, G.T. Marth, and M.-J. Gubbels. 2014. Whole genome profiling of spontaneous and chemical mutagenesis induced mutations in Toxoplasma gondii. BMC Genomics. 15: 354.
 

 Farrell, M., and M.-J. Gubbels 2014. TheToxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole). Cellular Microbiology, 16: 78-94  

Morlon-Guyot, J., L. Berry, C.-T. Chen, M.-J. Gubbels, M. Lebrun, and W. Daher. 2014. TheToxoplasma gondii  Calcium Dependent Protein Kinase 7 is involved in early steps of parasite division and crucial for parasite survival. Cellular Microbiology, 16: 95-114

Gubbels, M.-J., and N. Morrissette 2013. The cytoskeleton: structures and motility (Chapter 13). In i>Toxoplasma gondii: the model apicomplexan. 2nd edition.  Eds.: L.M. Weiss and K. Kim. Elsevier Academic Press. ISBN 9780123964816.

 

Gubbels, M.-J., and Morrissette, N. 2013. The Cytoskeleton: structures and motility (chapter 13). In: Toxoplasma gondii: The Model Apicomplexan, 2nd edition. Eds.: L.M. Weiss and K. Kim. Elsevier Academic Press. ISBN: 9780123964816

 

Yang, N., A. Farrell, W. Niedelman, M. Melo, D. Lu, L. Julien, G.T. Marth, M.-J. Gubbels, and J.P.J. Saeij. 2013. Genetic basis for phenotypic differences between different Toxoplasma  Type I strains. BMC Genomics, 14:467
 

Chen, C.-T., and M.-J. Gubbels. 2013. The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant. J. Cell Sci. 126:3344-3355.
 

Gubbels, M.-J., and M.D. Duraisingh. 2012. Evolution of apicomplexan secretory organelles. Int. J. Parasitol., 42:1071-1081 (invited review)  

Lorestani, A., F.D. Ivey, S. Thirugnanam, M.A. Busby, G.T. Marth, I. Cheeseman, and M.-J. Gubbels. 2012. Targeted proteomic dissection of Toxoplasma, cytoskeleton sub-compartments using MORN1. Cytoskeleton, 69:1069-1085  

Bushkin, G.G., P. Magnelli, E. Motari, M.-J. Gubbels, J.P. Dubey, K. Miska, E. Bullitt, C.E. Costello, P.W. Robbins, and J. Samuelson. 2012. β-1,3-glucan, a druggable target, is part of a trabecular scaffold in inner layer of the oocyst wall of Toxoplasma and Eimeria. mBio. 3(5). pii:e00258-12  

Anderson-White, B.R., J.R. Beck, C.-T. Chen, M. Meissner, P.J. Bradley, and M.-J. Gubbels. 2012. Cytoskeleton development of Toxoplasma gondii. Int. Rev. Cell Mol. Biol. 298:1-31. (invited review) 

Fung, C., J.R. Beck, S.D. Robertson, M.-J. Gubbels, and P.J. Bradley. 2012. Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation. Mol. Biochem. Parasitol. 184:99-108. PMCID: PMC3383393  

Szatanek, T., B.R. Anderson-White, D. Faugno-Fusci, M. White, J.P.J. Saeij, and M.-J. Gubbels. 2012. Cactin is essential for G1 progression of Toxoplasma gondii. Mol. Micro. 84:566-577. PMCID: PMC3331927. 

Coleman, B.I., and M.-J. Gubbels. 2012. A genetic screen to isolate Toxoplasma gondii host cell egress mutants. J. Vis. Exp. 60:pii3807  

Farrell, A*. S. Thirugnanam*, A. Lorestani*, J.D. Dvorin*, K.P. Eidell, B.R. Anderson-White, D.J.P. Ferguson, M.T. Duraisingh#, G.T. Marth#, and M.-J. Gubbels#. 2012. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 335:218-221  

Jammallo*, L., K. Eidell*, P.H. Davis, F.J. Dufort, C. Cronin, S. Thirugnanam, T.C. Chiles, D.S. Roos, and M.-J. Gubbels. 2011. An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene. Mol. Biochem. Parasitol. 175:133-143.  

Anderson-White, B.R., F.D. Ivey, K, K. Cheng, T. Szatanek, A. Lorestani, C.J. Beckers, D.J.P. Ferguson, N. Sahoo, and M.-J. Gubbels. 2011. A family of intermediate filament-like proteins is sequentially assembled into the cytoskeletal scaffold of Toxoplasma gondii. Cell Microbiol.13:18-31. 

Lorestani, A., L. Sheiner, K. Yang, S.D. Robertson, N. Sahoo, C.F. Brooks, D.P.J. Ferguson, B. Striepen, and M.-J. Gubbels. 2010. A Toxoplasma MORN1 null mutant is defective in basal complex assembly and apicoplast division. PLoS ONE. 5:e12302  

 

Eidell, K., T. Burke, and M.-J. Gubbels. 2010. Development of a screen to dissect Toxoplasma gondii egress. Mol Biochem Parasitol. 171:97-103  

 

Wilson, D.C., G.M. Grotenbreg, K.N. Liu, Y. Zhao, E.-M. Frickel,  M.-J. Gubbels, H.L. Ploegh, and G.S. Yap. 2010. Differential regulation of effector- and central-memory responses to Toxoplasma gondii infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathogens, 19:e1000815.  

Bushkin, G.G., D.M. Ratner, J. Cui, S. Banerjee, M.T. Duraisingh, C.V. Jennings, J.D. Dvorin, M.-J. Gubbels, S.D. Robertson, M. Steffen, B.R. O’Keefe, P.W. Robbins, and J. Samuelson. 2010. Evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Euk. Cell. 9:228-241.  

Frickel. E.M., N. Sahoo, J. Hopp, M.-J. Gubbels, M.P. Craver, L.J. Knoll, H. Ploegh, and G. Grotebreg. 2008. Parasite stage-specific recognition of endogenous Toxoplasma gondii epitopes by CD8+ T cells. J Inf. Dis. 98:1625-1633 .  

 

Gubbels M.-J., M. White and T. Szatanek. 2008. The cell cycle and Toxoplasma gondii cell division: Tightly knit or loosely stitched? Int. J. Parasitol. 38:1343-1358. (review) 

Muskavitch, M., N. Barteneva and M.-J. Gubbels. 2008. Chemogenomics and Parasitology: small molecules and cell-based assays to study infectious processes. Comb. Chem. HTS. 11:626-649. (review)  

Ferguson, D.J.P., N. Sahoo, R.A. Pinches, J.M. Bumstead, F.M. Tomley, and M.-J. Gubbels. 2008. MORN1 has a conserved role in asexual and sexual development across the Apicomplexa. Euk. Cell. 7(4):698-711.  

Gubbels, M.-J., C.F. Brooks, M. Muthalagi, T. Szatanek, J. Flynn, B. Parrot, B. Striepen and M.W. White. 2008. Forward genetic analysis of the apicomplexan cell and division cycle in Toxoplasma gondii. PLoS Pathogens, 4(2):e36.

 

Frickel, E.-M., V. Quesada, L. Muething, M.-J. Gubbels, E. Spooner, H. Ploegh and K. Artavanis-Tsakonas. 2007. UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution. Cell. Microbiol. 9:1601-1610.

University of Georgia

Gubbels, M.-J., J. Mazumdar, G. van Dooren and B. Striepen. 2007. Manipulating the Toxoplasma genome. In "The biology of Toxoplasma gondii". D. Soldati and J. Ajioka (eds.). Horizon Scientific Press, Norwich, UK.  

 

Andrade, R.M., M. Wessendarp, M.-J. Gubbels, B. Striepen, and C.S. Subauste. 2006. CD40 induces macrophage anti-microbial activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J. Clin. Invest. 116:2366-2377. 

 

Dalton, J.A., S.M. Cruickshank, C.E. Egan, R. Mears, D.J. Newton, E.M. Andrew, B. Lawrence, G. Howell, K.J. Else, M.-J. Gubbels, B. Striepen, J. Smith, S.J. White, and S.R. Carding. 2006. Intraepithelial gamma-delta positive lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology, 131:818-829.  

 

Gubbels, M.-J., S. Vaishnava, N. Boot, J.-F. Dubremetz and B. Striepen. 2006. A MORN-Repeat protein is a dynamic component of the cell division apparatus of the parasite Toxoplasma gondii. J. Cell Science. 119:2236-2245.  

 

Egan, C.E., J.E. Dalton, E.M. Andrew, J.E. Smith, M.-J. Gubbels, B. Striepen and S.R. Carding. 2005. A requirement for the Vgamma1+ subset of peripheral gamma-delta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J. Immunol. 175:8191-8199. 

 

 Howe, D.K., R. Gaji, M. Mroz-Barrett, M-J. Gubbels, B. Striepen, and S. Stamper. 2005. Sarcocystis neurona merozoites express a family of immunogenic surface antigens that are orthologues of the SAG/SRS surface antigens in Toxoplasma gondii. Infect. Immun. 73:1023-1033. 

 

Gubbels, M.-J., B. Striepen, N. Shastri, M. Turkoz, E. Robey. 2005. Class I MHC presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infect. Immun. 73:703-711. 

 

Gubbels, M.-J. and B. Striepen. 2004. Fluorescent proteins as tools to study the cell biology of protozoan parasites. (Review). Microsc. Microanal. 10:1-12. click here for a pdf  

 

Gubbels*, M.-J., M. Wieffer* and B. Striepen. 2004. Fluorescent protein tagging in Toxoplasma gondii: identification of novel inner membrane complex component conserved in Apicomplexa. Mol. Biochem. Parasitol. 137:99-110. 

 

Radke, J., M.J. Gubbels, B. Striepen and M. White. 2004. Identification of a sporozoite-specific member of the Toxoplasma SAG superfamily via genetic complementation. Mol. Microbiol. 52:93-105. 

 

Striepen, B., A.J.P. Pruijssers, J. Huang, C. Li, M.J. Gubbels, N.N. Umejiego, L. Hedstrom, J.C. Kissinger. 2004. Gene transfer in the evolution of parasite nucleotide biosynthesis. Proc. Natl. Acad. Sci USA, 101:3154-3159. 

 

Gubbels, M.-J., C. Li and B. Striepen. 2003. A high throughput growth assay for Toxoplasma gondii using yellow fluorescent protein. Antimicrob. Agents Chemother. 47: 309-316.

Universiteit Utrecht

Schnittger, L.,H. Yin, B. Qi, M.J. Gubbels, D. Beyer, S. Niemann, F. Jongejan and J. S. Ahmed. 2004. Simultaneous detection and differentiation of Theileria and Babesia parasites infecting small ruminants by reverse line blotting. Parastiol. Res. 92: 189-196 

 

Schnittger, L., H. Yin, M.J. Gubbels, D. Beyer, S. Niemann, F. Jongejan and J.S. Ahmed 2003. Phylogeny of sheep and goat Theileria and Babesia parasites. Parasitol. Res. 91:398-406. 

 

Gubbels, M.-J., H. Yin, Q. Bai, G. Liu, I.J. Nijman and F. Jongejan. 2002. The phylogenetic position of the Theileria buffeli group in relation to other Theileria species. Parasitol. Res. 88: S28-32. 

 

Gubbels, M.-J., F. Katzer, B.R. Shiels and F. Jongejan. 2001. Study of Theileria annulata population structure during bovine infection and following transmission to ticks. Parasitology 123: 553-561. 

 

Gubbels, J.M., E. de Vries and F. Jongejan. 2001 Moleculaire Diagnostiek van Parasieten. In M. van Berlo (ed.), Moleculaire Diagnostiek. Bohn Stafleu Van Loghum, Houten, The Netherlands. 

 

Gubbels, M.-J., F. Katzer, G. Hide, F. Jongejan and B.R. Shiels. 2000. Generation of a mosaic pattern of diversity in the major merozoite-piroplasm surface antigen of Theileria annulata. Mol. Biochem. Parasitol. 110: 23-32. 

 

Gubbels, M.-J., C. d’Oliveira and F. Jongejan. 2000. Development of an indirect Tams1 enzyme-linked-immunosorbent assay for diagnosis of Theileria annulata infection in cattle. Clin. Diag. Lab. Immunol. 7: 404-411. 

 

Gubbels, M.-J., H. Yin, M. van der Weide, Q. Bai, I.J. Nijman, G. Liu and F. Jongejan. 2000. Molecular and biological characterization of the Theileria buffeli/orientalis group. Int. J. Parasitol. 30: 943-952. 

 

Sparagano, O., M.-J. Gubbels, G.R. Loria, A.P. de Vos, S. Caracappa and F. Jongejan. 2000. Integrated molecular diagnosis of Theileria and Babesia species of cattle in Italy. Ann. N.Y. Acad. Sci. 916: 533-539. 

 

Gubbels, M.-J., J. Viseras, M.A. Habela and F. Jongejan. 2000. Characterization of attenuated Theileria annulata vaccines from Spain and the Sudan. Ann. N.Y. Acad. Sci. 916: 521-532. 

 

Sparagano, O., M.-J. Gubbels, A.P. de Vos and F. Jongejan. 1999. Multiple and specific identification of Piroplasmidae in hosts and vectors using an integrated molecular technique. Epidémiologie et Santé Animale 35: 81-85 (in French). 

 

Gubbels, J.M., A.P. de Vos, M. van der Weide, J. Viseras, E. de Vries, L.M. Schouls and F. Jongejan. 1999. Simultaneous detection of bovine Theileria and Babesia species using reverse line blot hybridization. J. Clin. Microbiol. 37: 1782-1789. 

 

Boulter, N., D. Brown, G. Wilkie, S. Williamson, E. Kirvar, P. Knight, E. Glass, J. Campbell, S. Morzaria, V. Nene, A. Musoke, C. d’Oliveira, M. Gubbels, F. Jongejan and R. Hall. 1999. Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems. Trop. Med. Int. Health 4: A71-A77. 

 

Boulter, N.R., C.G.D. Brown, E. Kirvar, E. Glass, J. Campbell, S. Morzaria, V. Nene, A. Musoke, C. d’Oliveira, M.-J. Gubbels, F. Jongejan and F.R. Hall. 1998. Different vaccine strategies used to protect against Theileria annulata. Ann. N.Y. Acad. Sci. 849: 234-246. 

 

Walhout, A.J.M., J.M. Gubbels, R. Bernards, P.C. van der Vliet and H.Th.M. Timmers. 1997. C-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene. Nucleic Acids Res. 25: 1493-1501.

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